CELLULAR PHENOTYPES OF GLIOBLASTOMA AND PROGNOSIS OF TUMOR OUTCOME

In solid malignant tumors, as well in hematological cancer stem cells (CSCs), quiescent, pluripotent, self-renewing neoplastic, also known tumor initiating cells, have been identified. CSC tumors are resistant not only to chemotherapy, but radiation therapy, they play their role the occurrence of relapses after surgical treatment, An unfavorable prognosis due an aggressive course and complications treatment most common primary brain - glioblastoma multiforme (GBM), is associated with CSC. One mechanisms that affect physiological regeneration tissues, do work under conditions malignancy, environment composition cellular ensemble, represented by phenotypes adaptive immunity. Using immunohistochemical phenotyping methods, authors identified immunocytes/phagocytes established features localization tissue at border around tumor. It was concluded apoptosis tumor, intercellular signaling migration focus process disrupted. The damage cambium genome, immature hematogenous pool, capable proliferating partially entering into incomplete differentiation hypoxia absence blood vessels. At second stage, connective formed, which grows vessels, wall endothelium, impaired transport function. According authors, metastasis does occur lymphogenous pathways, development additional foci hematopoiesis a result adaptation human body loss semi-stem precursors for normal nervous tissue.